the effect of sesamin on motor asymmetry in intrastriatal 6-hydroxydopamine rat model of parkinson's disease

Authors

tourandokht baluchnejadmojarad

monireh mansouri

farnaz nikbakht

soudabeh fallah

mehrdad roghani

abstract

background and objective: parkinson's disease (pd) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. l-dihydroxyphenylamine (l-dopa) therapy is currently the gold standard maneuver for pd. due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of this agent on motor asymmetry induced by intrastriatal injection of 6-hydroxydopamine in the rat. materials and methods: in this experimental research, male wistar rats (n=48) were equally divided into sham, sesamin20-treated sham, 6-hydroxydopamine (ohda)-lesioned, sesamin10 and sesamin20-treated lesion groups, and sesamin20-treated lesion group receiving the estrogenic antagonist fulvestrant. model of pd was induced by microinjecting 12.5 microgram of 6-ohda dissolved in normal saline-ascorbate solution into the left striatum. treated lesion groups received sesamin at doses of 10 or 20 mg/kg/day started one week till 1 h before the surgery. after 1 week, ipsilateral and contralateral rotations induced by apomorphine were counted and net scores were obtained. results: in the 6-ohda-lesioned group, the dopaminergic agonist apomorphine induced contralateral rotational behavior (pconclusion: sesamin administration at doses of 10 and 20 mg/kg could reduce motor asymmetry and attenuate forced biased rotational behavior in 6-ohda-induced model of pd and part of this effect is possibly via an estrogenic pathway.

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Journal title:
journal of basic and clinical pathophysiology

Publisher: shahed university

ISSN 2322-1895

volume 3

issue 2 2015

Keywords
[ ' s e s a m i n ' , 6 , ' h y d r o x y d o p a m i n e ' , ' r o t a t i o n a l b e h a v i o r ' , ' m o t o r a s y m m e t r y ' ]

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